The Impact of Vitamin A Deficiency on Tuberculosis Progression.

ABSTRACT:

Background

Although previous studies have shown that vitamin A deficiency is associated with incident tuberculosis (TB) disease, the direction of the association has not been established. We investigated the impact of vitamin A deficiency on TB disease progression.

Methods

We conducted a longitudinal cohort study nested within a randomized clinical trial among HIV-infected patients in Haiti. We compared serial vitamin A levels in individuals who developed TB disease to controls matched on age, gender, follow-up time, and time to antiretroviral therapy initiation. We also evaluated histopathology, bacterial load, and immune outcomes in TB infection in a guinea pig model of dietary vitamin A deficiency.

Results

Among 773 participants, 96 developed incident TB during fol

SUBMITTER: Podell BK 

PROVIDER: S-EPMC10200303 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature