A new metabolic model of Drosophila melanogaster and the integrative analysis of Parkinson's disease.

ABSTRACT: High conservation of the disease-associated genes between flies and humans facilitates the common use of Drosophila melanogaster to study metabolic disorders under controlled laboratory conditions. However, metabolic modeling studies are highly limited for this organism. We here report a comprehensively curated genome-scale metabolic network model of Drosophila using an orthology-based approach. The gene coverage and metabolic information of the draft model derived from a reference human model were expanded via Drosophila-specific KEGG and MetaCyc databases, with several curation steps to avoid metabolic redundancy and stoichiometric inconsistency. Furthermore, we performed literature-based curations to improve gene-reaction associations, subcellular metabolite locatio

SUBMITTER: Cesur MF 

PROVIDER: S-EPMC10215973 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature