APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia.

ABSTRACT:

Background

White matter hyperintensities, a neuroimaging marker of small-vessel cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are important dementia risk factors. However, APOE4 as a key effect modifier in the relationship between white matter hyperintensities and grey matter volume needs further exploration.

Methods

One hundred ninety-two early-stage dementia (including mild cognitive impairment and mild dementia) and 259 cognitively unimpaired participants from a neurocognitive research cohort with neuroimaging data, APOE genotyping, and neuropsychological assessments were studied. We investigated independent and interactive effects of white matter hyperintensities and APOE4 on whole-brain voxel-wise grey matter volume using voxel-based morphometry (uncorre

SUBMITTER: Vipin A 

PROVIDER: S-EPMC10239168 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature