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Plastic recognition and electrogenic uniport translocation of 1^st-, 2^nd-, and 3^rd-row transition and post-transition metals by primary-active transmembrane P_1B-2-type ATPase pumps.

ABSTRACT: Transmembrane P_1B-type ATPase pumps catalyze the extrusion of transition metal ions across cellular lipid membranes to maintain essential cellular metal homeostasis and detoxify toxic metals. Zn(ii)-pumps of the P_1B-2-type subclass, in addition to Zn²⁺, select diverse metals (Pb²⁺, Cd²⁺ and Hg²⁺) at their transmembrane binding site and feature promiscuous metal-dependent ATP hydrolysis in the presence of these metals. Yet, a comprehensive understanding of the transport of these metals, their relative translocation rates, and transport mechanism remain elusive. We developed a platform for the characterization of primary-active Zn(ii)-pumps in proteoliposomes to study metal selectivity, translocation events and transport mecha

SUBMITTER: Abeyrathna SS

PROVIDER: S-EPMC10246665 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Plastic recognition and electrogenic uniport translocation of 1^st-, 2^nd-, and 3^rd-row transition and post-transition metals by primary-active transmembrane P_1B-2-type ATPase pumps.

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Dataset Information

Plastic recognition and electrogenic uniport translocation of 1st-, 2nd-, and 3rd-row transition and post-transition metals by primary-active transmembrane P1B-2-type ATPase pumps.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Plastic recognition and electrogenic uniport translocation of 1^st-, 2^nd-, and 3^rd-row transition and post-transition metals by primary-active transmembrane P_1B-2-type ATPase pumps.