CD4⁺ T cells aggravate hemorrhagic brain injury.

ABSTRACT: Leukocyte infiltration accelerates brain injury following intracerebral hemorrhage (ICH). Yet, the involvement of T lymphocytes in this process has not been fully elucidated. Here, we report that CD4⁺ T cells accumulate in the perihematomal regions in the brains of patients with ICH and ICH mouse models. T cells activation in the ICH brain is concurrent with the course of perihematomal edema (PHE) development, and depletion of CD4⁺ T cells reduced PHE volumes and improved neurological deficits in ICH mice. Single-cell transcriptomic analysis revealed that brain-infiltrating T cells exhibited enhanced proinflammatory and proapoptotic signatures. Consequently, CD4⁺ T cells disrupt the blood-brain barrier integrity and promote PHE progression through interleuk

SUBMITTER: Shi SX 

PROVIDER: S-EPMC10246900 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature