Repurposing antifungal drugs for cancer therapy.

ABSTRACT:

Background

Repurposing antifungal drugs in cancer therapy has attracted unprecedented attention in both preclinical and clinical research due to specific advantages, such as safety, high-cost effectiveness and time savings compared with cancer drug discovery. The surprising and encouraging efficacy of antifungal drugs in cancer therapy, mechanistically, is attributed to the overlapping targets or molecular pathways between fungal and cancer pathogenesis. Advancements in omics, informatics and analytical technology have led to the discovery of increasing "off-site" targets from antifungal drugs involved in cancerogenesis, such as smoothened (D477G) inhibition from itraconazole in basal cell carcinoma.

Aim of review

This review illustrates several antifungal drugs repurposed f

SUBMITTER: Weng N 

PROVIDER: S-EPMC10248799 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature