Effect of Broad-Spectrum Antibiotic De-escalation on Critically Ill Patient Outcomes: A Retrospective Cohort Study.

ABSTRACT:

Purpose

Antibiotic de-escalation (ADE) in critically ill patients is controversial. Previous studies mainly focused on mortality; however, data are lacking about superinfection. Therefore, we aimed to identify the impact of ADE versus continuation of therapy on superinfections rate and other outcomes in critically ill patients.

Methods

This was a two-center retrospective cohort study of adults initiated on broad-spectrum antibiotics in the intensive care unit (ICU) for ≥ 48 h. The primary outcome was the superinfection rate. Secondary outcomes included 30-day infection recurrence, ICU and hospital length of stay, and mortality.

Results

250 patients were included, 125 in each group (ADE group and continuation group). Broad spectrum antibiotic discontinuation occurred a

SUBMITTER: Aldardeer N 

PROVIDER: S-EPMC10255942 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature