Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis.

ABSTRACT:

Background

The prognostic significance of non-disabling relapses in people with relapsing-remitting multiple sclerosis (RRMS) is unclear.

Objective

To determine whether early non-disabling relapses predict disability accumulation in RRMS.

Methods

We redefined mild relapses in MSBase as 'non-disabling', and moderate or severe relapses as 'disabling'. We used mixed-effects Cox models to compare 90-day confirmed disability accumulation events in people with exclusively non-disabling relapses within 2 years of RRMS diagnosis to those with no early relapses; and any early disabling relapses. Analyses were stratified by disease-modifying therapy (DMT) efficacy during follow-up.

Results

People who experienced non-disabling relapses within 2 years of RRMS diagnosis acc

SUBMITTER: Daruwalla C 

PROVIDER: S-EPMC10278381 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature