Dataset Information

Glycemic control and outcome after carotid intervention in patients with T2D: A Swedish nationwide cohort study.

ABSTRACT:

Aims

To investigate the association between glycemic control and outcome in people with type 2 diabetes (T2D) after carotid intervention due to carotid stenosis.

Methods

Observational nationwide population-based cohort study using inverse probability treatment weighting (IPTW) and Cox regressions with covariates, that is, 4 stepwise models, investigating the relationship between terciles of glycated hemoglobin (HbA1c) levels and stroke or death.

Results

1115 subjects with T2D undergoing carotid intervention were included during Jan 1st 2009 to Dec 31st 2015. Divided into terciles, with a mean HbA1c level of 44 (tercile 1), 53 (tercile 2), and 72 (tercile 3) mmol/mol. By using IPTW and Cox regression, each model was stepwise introduced for the investigating of relative risks, that is, hazard ratios (HRs) with associated 95% confidence intervals (CI). There was a significant increased risk for stroke or death, in every model observed for tercile 3, compared to tercile 1: HR for model 4: 1.35 (95% CI 1.02-1.78). No difference for stroke or death within 30 days was observed between the groups.

Conclusion

Poor glycemic control in people with T2D after carotid intervention is associated with an increased long-term risk for stroke or death.

SUBMITTER: Zabala A

PROVIDER: S-EPMC10286178 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature

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Publications

Glycemic control and outcome after carotid intervention in patients with T2D: A Swedish nationwide cohort study.

Zabala Alexander A Gottsäter Anders A Lind Marcus M Eliasson Björn B Bertilsson Rebecka R Ekelund Jan J Jonsson Magnus M Nyström Thomas T

Diabetes & vascular disease research 20230501 3

<h4>Aims</h4>To investigate the association between glycemic control and outcome in people with type 2 diabetes (T2D) after carotid intervention due to carotid stenosis.<h4>Methods</h4>Observational nationwide population-based cohort study using inverse probability treatment weighting (IPTW) and Cox regressions with covariates, that is, 4 stepwise models, investigating the relationship between terciles of glycated hemoglobin (HbA1c) levels and stroke or death.<h4>Results</h4>1115 subjects with T ...[more]

PMID: 37340709

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Project description:BackgroundColorectal cancer (CRC) incidence is increasing among young adults below screening age, despite the effectiveness of screening in older populations. Individuals with diabetes mellitus are at increased risk of early-onset CRC. We aimed to determine how many years earlier than the general population patients with diabetes with/without family history of CRC reach the threshold risk at which CRC screening is recommended to the general population.Methods and findingsA nationwide cohort study (follow-up:1964-2015) involving all Swedish residents born after 1931 and their parents was carried out using record linkage of Swedish Population Register, Cancer Registry, National Patient Register, and Multi-Generation Register. Of 12,614,256 individuals who were followed between 1964 and 2015 (51% men; age range at baseline 0-107 years), 162,226 developed CRC, and 559,375 developed diabetes. Age-specific 10-year cumulative risk curves were used to draw conclusions about how many years earlier patients with diabetes reach the 10-year cumulative risks of CRC in 50-year-old men and women (most common age of first screening), which were 0.44% and 0.41%, respectively. Diabetic patients attained the screening level of CRC risk earlier than the general Swedish population. Men with diabetes reached 0.44% risk at age 45 (5 years earlier than the recommended age of screening). In women with diabetes, the risk advancement was 4 years. Risk was more pronounced for those with additional family history of CRC (12-21 years earlier depending on sex and benchmark starting age of screening). The study limitations include lack of detailed information on diabetes type, lifestyle factors, and colonoscopy data.ConclusionsUsing high-quality registers, this study is, to our knowledge, the first one that provides novel evidence-based information for risk-adapted starting ages of CRC screening for patients with diabetes, who are at higher risk of early-onset CRC than the general population.

Dataset Information

Glycemic control and outcome after carotid intervention in patients with T2D: A Swedish nationwide cohort study.

Aims

Methods

Results

Conclusion

Publications

Glycemic control and outcome after carotid intervention in patients with T2D: A Swedish nationwide cohort study.

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