Multicenter analysis of immunosuppressive medications on the risk of malignancy following adult solid organ transplantation.

ABSTRACT:

Objective

This study aimed to assess the risk of maintenance immunosuppression on the post-transplant risk of malignancy across all solid organ transplant types.

Methods

This is a retrospective cohort study from a multicenter hospital system in the United States. The electronic health record was queried from 2000 to 2021 for cases of solid organ transplant, immunosuppressive medications, and post-transplant malignancy.

Results

A total of 5,591 patients, 6,142 transplanted organs, and 517 post-transplant malignancies were identified. Skin cancer was the most common type of malignancy at 52.8%, whereas liver cancer was the first malignancy to present at a median time of 351 days post-transplant. Heart and lung transplant recipients had the highest rate of malignancy, bu

SUBMITTER: Shaw R 

PROVIDER: S-EPMC10313202 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature