HECT, UBA and WWE domain containing 1 represses cholesterol efflux during CD4⁺ T cell activation in Sjogren's syndrome.

ABSTRACT: Introduction: Sjögren's syndrome (SS) is a chronic autoimmune disorder characterized by exocrine gland dysfunction, leading to loss of salivary function. Histological analysis of salivary glands from SS patients reveals a high infiltration of immune cells, particularly activated CD4⁺ T cells. Thus, interventions targeting abnormal activation of CD4⁺ T cells may provide promising therapeutic strategies for SS. Here, we demonstrate that Hect, uba, and wwe domain containing 1 (HUWE1), a member of the eukaryotic Hect E3 ubiquitin ligase family, plays a critical role in CD4⁺ T-cell activation and SS pathophysiology. Methods: In the context of HUWE1 inhibition, we investigated the impact of the HUWE1 inhibitor BI8626 and sh-Huwe1 on CD4⁺

SUBMITTER: Yin J 

PROVIDER: S-EPMC10330700 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature