RNF157 attenuates CD4⁺ T cell-mediated autoimmune response by promoting HDAC1 ubiquitination and degradation.

ABSTRACT: Background: CD4⁺ T cells play an important role in body development and homeostasis. Quantitative and functional changes in CD4⁺ T cells result in abnormal immune responses, which lead to inflammation, cancer, or autoimmune diseases, such as multiple sclerosis (MS). Ubiquitination plays an essential role in the differentiation and functioning of CD4⁺ T cells. However, the function of several E3 ubiquitin ligases in CD4⁺ T cell differentiation and T cell-mediated pathological diseases remains unclear. Methods: RNA sequencing data were analyzed to identify the E3 ubiquitin ligases that participate in the pathogenesis of MS. Furthermore, conditional knockout mice were generated. Specifically, flow cytometry, qPCR, western blot, CO-IP a

SUBMITTER: Wang P 

PROVIDER: S-EPMC10334825 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature