Human prostate organoid generation and the identification of prostate development drivers using inductive rodent tissues.

ABSTRACT: The reactivation of developmental genes and pathways during adulthood may contribute to pathogenesis of diseases such as prostate cancer. Analysis of the mechanistic links between development and disease could be exploited to identify signalling pathways leading to disease in the prostate. However, the mechanisms underpinning prostate development require further characterisation to interrogate fully the link between development and disease. Previously, our group developed methods to produce prostate organoids using induced pluripotent stem cells (iPSCs). Here, we show that human iPSCs can be differentiated into prostate organoids using neonatal rat seminal vesicle mesenchyme in vitro. The organoids can be used to study prostate development or modified to study prostate cancer. We also eluc

SUBMITTER: Singh P 

PROVIDER: S-EPMC10357030 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature