Lipoprotein(a) and the Risk for Recurrent Atherosclerotic Cardiovascular Events Among Adults With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study.

ABSTRACT:

Rationale & objective

Many adults with chronic kidney disease (CKD) and atherosclerotic cardiovascular disease (ASCVD) have high lipoprotein(a) levels. It is unclear whether high lipoprotein(a) levels confer an increased risk for recurrent ASCVD events in this population. We estimated the risk for recurrent ASCVD events associated with lipoprotein(a) in adults with CKD and prevalent ASCVD.

Study design

Observational cohort study.

Setting & participants

We included 1,439 adults with CKD and prevalent ASCVD not on dialysis enrolled in the Chronic Renal Insufficiency Cohort study between 2003 and 2008.

Exposure

Baseline lipoprotein(a) mass concentration, measured using a latex-enhanced immunoturbidimetric assay.

Outcomes

Recurrent ASCVD events (primary outc

SUBMITTER: Poudel B 

PROVIDER: S-EPMC10363548 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature