Matrix Metalloproteinase-2 and CKD Progression: The Chronic Renal Insufficiency Cohort (CRIC) Study.

ABSTRACT:

Rationale & objective

Matrix metalloproteinase 2 (MMP-2) plays an important role in the development of fibrosis, the final common pathway of chronic kidney disease (CKD). This study aimed to assess the relationship between repeated measures of MMP-2 and CKD progression in a large, diverse prospective cohort.

Study design

In a prospective cohort of Chronic Renal Insufficiency Cohort (CRIC) participants (N = 3,827), MMP-2 was measured at baseline. In a case-cohort design, MMP-2 was additionally measured at year 2 in a randomly selected subcohort and cases of estimated glomerular filtration rate (eGFR) halving or kidney replacement therapy (KRT) (N = 1,439).

Setting & participants

CRIC is a multicenter prospective cohort of adults with CKD.

Exposure

MMP-2 measured

SUBMITTER: Baudier RL 

PROVIDER: S-EPMC11315214 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature