Association of coffee consumption with type 2 diabetes and glycemic traits: a Mendelian randomization study.

ABSTRACT:

Background/objectives

Habitual coffee consumption was inversely associated with type 2 diabetes (T2D) and hyperglycemia in observational studies, but the causality of the association remains uncertain. This study tested a causal association of genetically predicted coffee consumption with T2D using the Mendelian randomization (MR) method.

Subjects/methods

We used five single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) associated with habitual coffee consumption in a previous genome-wide association study among Koreans. We analyzed the associations between IVs and T2D, fasting blood glucose (FBG), 2h-postprandial glucose (2h-PG), and glycated haemoglobin (HbA1C) levels. The MR results were further evaluated by standard sensitivity tests for possible pleiot

SUBMITTER: Cho HJ 

PROVIDER: S-EPMC10375333 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature