Specificity of Psychiatric Polygenic Risk Scores and Their Effects on Associated Risk Phenotypes.

ABSTRACT:

Background

Polygenic risk scores (PRSs) are indices of genetic liability for illness, but their clinical utility for predicting risk for a specific psychiatric disorder is limited. Genetic overlap among disorders and their effects on allied phenotypes may be a possible explanation, but this has been difficult to quantify given focus on singular disorders and/or allied phenotypes.

Methods

We constructed PRSs for 5 psychiatric disorders (schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, attention-deficit/hyperactivity disorder) and 3 nonpsychiatric control traits (height, type II diabetes, irritable bowel disease) in the UK Biobank (N = 31,616) and quantified associations between PRSs and phenotypes allied with mental illness: behavio

SUBMITTER: Rodrigue AL 

PROVIDER: S-EPMC10382704 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature