Model-Informed Precision Dosing Software Tools for Dosage Regimen Individualization: A Scoping Review.

ABSTRACT:

Background

Pharmacokinetic nomograms, equations, and software are considered the main tools available for Therapeutic Drug Monitoring (TDM). Model-informed precision dosing (MIPD) is an advanced discipline of TDM that allows dose individualization, and requires a software for knowledge integration and statistical calculations. Due to its precision and extensive applicability, the use of these software is widespread in clinical practice. However, the currently available evidence on these tools remains scarce.

Objectives

To review and summarize the available evidence on MIPD software tools to facilitate its identification, evaluation, and selection by users.

Methods

An electronic literature search was conducted in MEDLINE, EMBASE, OpenAIRE, and BASE before July 2022. Th

SUBMITTER: Del Valle-Moreno P 

PROVIDER: S-EPMC10386689 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature