GDF10 is related to obesity as an adipokine derived from subcutaneous adipose tissue.

ABSTRACT:

Introduction

Adipokines are proteins that are secreted by the adipose tissue. Although they are associated with obesity-related metabolic disorders, most studies have focused on adipokines expressed by visceral adipose tissue (VAT). This study aimed to identify the adipokine potentially derived from subcutaneous adipose tissue (SAT) and its clinical significance.

Methods

Samples of SAT and VAT were obtained from six adult male patients who underwent laparoscopic surgery for benign gall bladder disease. Differentially expressed genes were analyzed by subjecting the samples to RNA sequencing. The serum concentration of selected proteins according to body mass index (BMI) was analyzed in 58 individuals.

Results

GDF10 showed significantly higher expression in the S

SUBMITTER: Song MK 

PROVIDER: S-EPMC10390302 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature