CCIDB: a manually curated cell-cell interaction database with cell context information.

ABSTRACT: Cell-cell interaction (CCI) is a crucial event in the development and function of multicellular organisms. The development of CCI databases is beneficial for researchers who want to analyze single-cell sequencing data or study CCI through molecular experiments. CCIs are known to act differently according to cellular and biological contexts such as cell types, gene mutations or disease status; however, previous CCI databases do not completely provide this contextual information pertaining to CCIs. We constructed a cell-cell interaction database (CCIDB) containing the biological and clinical contexts involved in each interaction. To build a database of cellular and tissue contexts, we collected 38 types of context features, which were categorized into seven categories, including 'interaction

SUBMITTER: Noh JY 

PROVIDER: S-EPMC10419333 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature