Lower versus higher oxygenation targets in ICU patients with haematological malignancy - insights from the HOT-ICU trial.

ABSTRACT:

Background

Patients admitted to an intensive care unit (ICU) with active haematological malignancy and hypoxaemic respiratory failure have a high mortality. Oxygen supplementation is essential, but limited information exists on the optimum oxygenation targets in these patients.

Methods

This subgroup analysis was specified before completion of the Handling Oxygenation Targets in the ICU (HOT-ICU) trial. The trial investigated the effects of a lower (8 kPa) vs a higher (12 kPa) arterial oxygenation target and was stratified for active haematological malignancy, chronic obstructive pulmonary disease, and site. We here report the primary outcome (90-day mortality) and selected secondary outcomes in the subgroup of patients with active haematological malignancy.

Results

SUBMITTER: Klitgaard TL 

PROVIDER: S-EPMC10430820 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature