Fiber-specific micro- and macroscopic white matter alterations in progressive supranuclear palsy and corticobasal syndrome.
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ABSTRACT:
SUBMITTER: Uchida W
PROVIDER: S-EPMC10435458 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Publications
Fiber-specific micro- and macroscopic white matter alterations in progressive supranuclear palsy and corticobasal syndrome.
Uchida Wataru W Kamagata Koji K Andica Christina C Takabayashi Kaito K Saito Yuya Y Owaki Mana M Fujita Shohei S Hagiwara Akifumi A Wada Akihiko A Akashi Toshiaki T Sano Katsuhiro K Hori Masaaki M Aoki Shigeki S
NPJ Parkinson's disease 20230817 1
Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are characterized by progressive white matter (WM) alterations associated with the prion-like spreading of four-repeat tau, which has been pathologically confirmed. It has been challenging to monitor the WM degeneration patterns underlying the clinical deficits in vivo. Here, a fiber-specific fiber density and fiber cross-section, and their combined measure estimated using fixel-based analysis (FBA), were cross-sectionally and ...[more]
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