Identifying target organ location of Radix Achyranthis Bidentatae: a bioinformatics approach on active compounds and genes.

ABSTRACT: Background: Herbal medicines traditionally target organs for treatment based on medicinal properties, and this theory is widely used for prescriptions. However, the scientific evidence explaining how herbs act on specific organs by biological methods has been still limited. This study used bioinformatic tools to identify the target organ locations of Radix Achyranthis Bidentatae (RAB), a blood-activating herb that nourishes the liver and kidney, strengthens bones, and directs prescription to the lower body. Methods: RAB's active compounds and targets were collected and predicted using databases such as TCMSP, HIT2.0, and BATMAN-TCM. Next, the RAB's target list was analyzed based on two approaches to obtain target organ locations. DAVID and Gene ORGANizer enrichment-based appr

SUBMITTER: Tran MN 

PROVIDER: S-EPMC10448535 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature