Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury.

ABSTRACT:

Background

Impaired ex vivo platelet aggregation is common in trauma patients. The mechanisms driving these impairments remain incompletely understood, but functional platelet exhaustion due to excessive in vivo activation is implicated. Given platelet adrenoreceptors and known catecholamine surges after injury, impaired ex vivo platelet aggregation in trauma patients may be linked to catecholamine-induced functional platelet exhaustion.

Objective

To determine the relationship of catecholamines with platelet-dependent hemostasis after injury and to model catecholamine-induced functional platelet exhaustion in healthy donor platelets.

Patients/methods

Whole blood was collected from 67 trauma patients as part of a prospective cohort study. Platelet aggregometry and rota

SUBMITTER: Matthay ZA 

PROVIDER: S-EPMC10450647 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature