Polygenic Risk Score Predicts Sudden Death in Patients With Coronary Disease and Preserved Systolic Function.

ABSTRACT:

Background

A familial predisposition to sudden and/or arrhythmic death (SAD) in the setting of coronary artery disease (CAD) exists; however, the genetic basis is poorly understood.

Objectives

The purpose of this study was to determine whether a genome-wide polygenic score for coronary artery disease (GPS_CAD) might have utility in SAD risk stratification in CAD patients without severe systolic dysfunction.

Methods

A previously validated GPS_CAD was generated utilizing genome-wide genotyping in 4,698 PRE-DETERMINE participants of European ancestry with CAD and left ventricular ejection fraction >30%-35%. The population was dichotomized according to top GPS_CAD decile as defined by the general population, and absolute, proportional, and re

SUBMITTER: Sandhu RK 

PROVIDER: S-EPMC10460525 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature