Vitamin D status modulates innate immune responses and metabolomic profiles following acute prolonged cycling.

ABSTRACT:

Purpose

The influence of vitamin D status on exercise-induced immune dysfunction remains unclear. The aim of this study was to investigate the effects of vitamin D status (circulating 25(OH)D) on innate immune responses and metabolomic profiles to prolonged exercise.

Methods

Twenty three healthy, recreationally active males (age 25 ± 7 years; maximal oxygen uptake [[Formula: see text]max] 56 ± 9 mL·kg^-1·min^-1), classified as being deficient (n = 7) or non-deficient n = 16) according to plasma concentrations of 25(OH)D, completed 2.5 h of cycling at 15% Δ (~ 55-60% [Formula: see text]max). Venous blood and unstimulated saliva samples were obtained before and after exercise.

Results

Participants with deficient plasma 25(OH)D on average had lower to

SUBMITTER: Jones AW 

PROVIDER: S-EPMC10468936 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature