Dataset Information

Associations between cadmium exposure and whole-body aging: mediation analysis in the NHANES.

ABSTRACT:

Introduction

Even though cadmium (Cd) exposure and cellular senescence (telomere length) have been linked in previous studies, composite molecular aging biomarkers are more significant and reliable factors to consider when examining the connection between metal exposure and health outcomes. The purpose of this research was to assess the association between urinary cadmium (U-Cd) and whole-body aging (phenotypic age).

Methods

Phenotypic age was calculated from chronological age and 9 molecular biomarkers. Multivariate linear regression models, subgroup analysis, and smoothing curve fitting were used to explore the linear and nonlinear relationship between U-Cd and phenotypic age. Mediation analysis was performed to explore the mediating effect of U-Cd on the association between smoking and phenotypic age.

Results

This study included 10,083 participants with a mean chronological age and a mean phenotypic age of 42.24 years and 42.34 years, respectively. In the fully adjusted model, there was a positive relationship between U-Cd and phenotypic age [2.13 years per 1 ng/g U-Cd, (1.67, 2.58)]. This association differed by sex, age, and smoking subgroups (P for interaction < 0.05). U-Cd mediated a positive association between serum cotinine and phenotypic age, mediating a proportion of 23.2%.

Conclusions

Our results suggest that high levels of Cd exposure are associated with whole-body aging.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC10469832 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Publications

Associations between cadmium exposure and whole-body aging: mediation analysis in the NHANES.

Zhang Ya Y Liu Mingjiang M Xie Ruijie R

BMC public health 20230831 1

<h4>Introduction</h4>Even though cadmium (Cd) exposure and cellular senescence (telomere length) have been linked in previous studies, composite molecular aging biomarkers are more significant and reliable factors to consider when examining the connection between metal exposure and health outcomes. The purpose of this research was to assess the association between urinary cadmium (U-Cd) and whole-body aging (phenotypic age).<h4>Methods</h4>Phenotypic age was calculated from chronological age and ...[more]

PMID: 37653508

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Dataset Information

Associations between cadmium exposure and whole-body aging: mediation analysis in the NHANES.

Introduction

Methods

Results

Conclusions

Publications

Associations between cadmium exposure and whole-body aging: mediation analysis in the NHANES.

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