Propagation of activity through the cortical hierarchy and perception are determined by neural variability.

ABSTRACT: Brains are composed of anatomically and functionally distinct regions performing specialized tasks, but regions do not operate in isolation. Orchestration of complex behaviors requires communication between brain regions, but how neural dynamics are organized to facilitate reliable transmission is not well understood. Here we studied this process directly by generating neural activity that propagates between brain regions and drives behavior, assessing how neural populations in sensory cortex cooperate to transmit information. We achieved this by imaging two densely interconnected regions-the primary and secondary somatosensory cortex (S1 and S2)-in mice while performing two-photon photostimulation of S1 neurons and assigning behavioral salience to the photostimulation. We found that the p

SUBMITTER: Rowland JM 

PROVIDER: S-EPMC10471496 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature