Association between inflammatory bowel disease and pancreatic cancer: results from the two-sample Mendelian randomization study.

ABSTRACT:

Background

The nuanced relationship between inflammatory bowel disease (IBD) and pancreatic cancer is noticed in recent years. However, the underlying causal effects of these two diseases are still unclear.

Methods

The two-sample mendelian randomization (MR) was conducted to explore the causal effect of IBD condition on pancreatic cancer. Methods of Wald ratio, inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode were used to investigate the causal relationship between IBD and pancreatic cancer. Besides, Cochrane's Q test, MR-Egger, and leave-one-out method were further conducted to detect heterogeneity, stability, and pleiotropy of MR results.

Results

In the MR analysis, we found Crohn's disease had a significant causal effect on pancreatic c

SUBMITTER: Min Y 

PROVIDER: S-EPMC10492092 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature