Increased glutamate in type 2 diabetes in the Korean population is associated with increased plasminogen levels.

ABSTRACT:

Background

Glutamate is a major neurotransmitter, although it causes cytotoxicity and inflammation in nonneuronal organs. This study aimed to investigate the metabolic disorders in which glutamate, associated with type 2 diabetes onset, is induced in the liver.

Methods

An analysis of Korean community-based Ansan-Ansung cohort study data as well as functional research using in vitro and mouse models were performed.

Results

Groups with high plasma glutamate levels (T2, T3) had a significantly increased risk of diabetes incidence after 8 years, compared to the group with relatively low glutamate levels (T1). Analysis of the effect of glutamate on diabetes onset in vitro showed that glutamate induces insulin resistance by increasing glucose-related protein 78 (GRP78) and

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC10509517 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature