Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration.
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ABSTRACT:
SUBMITTER: Mikkelsen RB
PROVIDER: S-EPMC9763857 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
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Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration.
Mikkelsen Randi Bonke RB Arora Tulika T Trošt Kajetan K Dmytriyeva Oksana O Jensen Sune Kjærsgaard SK Meijnikman Abraham Stijn AS Olofsson Louise Elisabeth LE Lappa Dimitra D Aydin Ömrüm Ö Nielsen Jens J Gerdes Victor V Moritz Thomas T van de Laar Arnold A de Brauw Maurits M Nieuwdorp Max M Hjorth Siv Annegrethe SA Schwartz Thue Walter TW Bäckhed Fredrik F
iScience 20221126 12
Obesity and diabetes are associated with inflammation and altered plasma levels of several metabolites, which may be involved in disease progression. Some metabolites can activate G protein-coupled receptors (GPCRs) expressed on immune cells where they can modulate metabolic inflammation. Here, we find that 3-hydroxydecanoate is enriched in the circulation of obese individuals with type 2 diabetes (T2D) compared with nondiabetic controls. Administration of 3-hydroxydecanoate to mice promotes imm ...[more]
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