Cardiac Risk Factors for Stroke: A Comprehensive Mendelian Randomization Study.

ABSTRACT:

Background

Observational studies suggest an association of stroke with cardiac traits beyond atrial fibrillation, the leading source of cardioembolism. However, controversy remains regarding a causal role of these traits in stroke pathogenesis. Here, we leveraged genetic data to systematically assess associations between cardiac traits and stroke risk using a Mendelian Randomization framework.

Methods

We studied 66 cardiac traits including cardiovascular diseases, magnetic resonance imaging-derived cardiac imaging, echocardiographic imaging, and electrocardiographic measures, as well as blood biomarkers in a 2-sample Mendelian Randomization approach. Genetic predisposition to each trait was explored for associations with risk of stroke and stroke subtypes in data from the ME

SUBMITTER: Frerich S 

PROVIDER: S-EPMC10510836 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature