The Effect of Genetic HLA Matching on Liver Transplantation Outcome: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

We aim to investigate the effects of genetically based HLA matching on patient and graft survival, and acute and chronic rejection after liver transplantation.

Background

Liver transplantation is a common treatment for patients with end-stage liver disease. In contrast to most other solid organ transplantations, there is no conclusive evidence supporting human leukocyte antigen (HLA) matching for liver transplantations. With emerging alternatives such as transplantation of bankable (stem) cells, HLA matching becomes feasible, which may decrease the need for immunosuppressive therapy and improve transplantation outcomes.

Methods

We systematically searched the PubMed, Embase, and Cochrane databases and performed a meta-analysis investigating the effect of gene

SUBMITTER: Kok G 

PROVIDER: S-EPMC10513352 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature