MiR-365-3p mediates BCL11A and SOX6 erythroid-specific coregulation: A new player in HbF activation.

ABSTRACT: Hemoglobin switching is a complex biological process not yet fully elucidated. The mechanism regulating the suppression of fetal hemoglobin (HbF) expression is of particular interest because of the positive impact of HbF on the course of diseases such as β-thalassemia and sickle cell disease, hereditary hemoglobin disorders that affect the health of countless individuals worldwide. Several transcription factors have been implicated in the control of HbF, of which BCL11A has emerged as a major player in HbF silencing. SOX6 has also been implicated in silencing HbF and is critical to the silencing of the mouse embryonic hemoglobins. BCL11A and SOX6 are co-expressed and physically interact in the erythroid compartment during differentiation. In this study, we observe that BCL11A knocko

SUBMITTER: Simbula M 

PROVIDER: S-EPMC10514143 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature