Effect of high dose vitamin D₃ on the HIV-1 reservoir: A pilot randomised controlled trial.

ABSTRACT:

Introduction

Antiretroviral therapy for people living with HIV-1 must be taken lifelong due to the persistence of latent virus in long-lived and proliferating CD4⁺ T cells. Vitamin D₃ is a steroidal gene transcription regulator which exerts diverse effects on immune and epithelial cells including reductions in CD4⁺ T cell proliferation and improvement in gut barrier integrity. We hypothesised that a high dose of vitamin D₃ would reduce the size of the HIV-1 reservoir by reducing CD4⁺ T cell proliferation.

Methods

We performed a randomised placebo-controlled trial evaluating the effect of 24 weeks of vitamin D₃ (10,000 international units per day) on the HIV-1 reservoir and immunologic parameters in 30 adults o

SUBMITTER: Pitman MC 

PROVIDER: S-EPMC10518338 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature