Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis.
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ABSTRACT:
SUBMITTER: Yang WH
PROVIDER: S-EPMC10518488 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
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Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis.
Yang Won Ho WH Aziz Peter V PV Heithoff Douglas M DM Kim Yeolhoe Y Ko Jeong Yeon JY Cho Jin Won JW Mahan Michael J MJ Sperandio Markus M Marth Jamey D JD
iScience 20230909 10
The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not well understood. We have applied a recurrent food poisoning model of acquired inflammatory bowel disease using <i>Salmonella enterica</i> Typhimurium to investigate mucosal barrier erosion. Our findings reveal an innate Toll-like receptor 4-dependent mechanism a ...[more]
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