Novel functional atrial fibrillation risk genes and pathways identified from coexpression analyses in human left atria.

ABSTRACT:

Background

Genomewide association studies have associated >100 genetic loci with atrial fibrillation (AF), but establishing causal genes contributing to AF remains challenging.

Objective

The purpose of this study was to determine candidate novel causal genes and mechanistic pathways associated with AF risk loci by incorporating gene expression and coexpression analyses and to provide a resource for functional studies and targeting of AF-associated genes.

Methods

Cis-expression quantitative trait loci were identified for candidate genes near AF risk variants in human left atrial tissues. Coexpression partners were identified for each candidate gene. Weighted gene coexpression network analysis (WGCNA) identified modules and modules with overrepresentation of candidate A

SUBMITTER: Wass SY 

PROVIDER: S-EPMC10527093 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature