Obesity-induced dysregulation of skin-resident PPARγ⁺ Treg cells promotes IL-17A-mediated psoriatic inflammation.

ABSTRACT: Obesity is a major risk factor for psoriasis, but how obesity disrupts the regulatory mechanisms that keep skin inflammation in check is unclear. Here, we found that skin was enriched with a unique population of CD4⁺Foxp3⁺ regulatory T (Treg) cells expressing the nuclear receptor peroxisome proliferation-activated receptor gamma (PPARγ). PPARγ drove a distinctive transcriptional program and functional suppression of IL-17A⁺ γδ T cell-mediated psoriatic inflammation. Diet-induced obesity, however, resulted in a reduction of PPARγ⁺ skin Treg cells and a corresponding loss of control over IL-17A⁺ γδ T cell-mediated inflammation. Mechanistically, PPARγ⁺ skin Treg cells preferentially took up elevated levels of long-chain free fa

SUBMITTER: Sivasami P 

PROVIDER: S-EPMC10527179 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature