A fixed 20:1 combination of cafedrine/theodrenaline increases cytosolic Ca²⁺ concentration in human tracheal epithelial cells via ryanodine receptor-mediated Ca²⁺ release.

ABSTRACT: Mucociliary clearance is a pivotal physiological mechanism that protects the lung by cleaning the airways from pollution and colonization, thereby preventing infection. Ciliary function is influenced by various signal transduction cascades, and Ca²⁺ represents a key second messenger. A fixed 20:1 combination of cafedrine and theodrenaline has been widely used to treat perioperative hypotension and emergency hypotensive states since the 1960s; however, its effect on the intracellular Ca²⁺ concentration ([Ca²⁺]_i) of respiratory epithelium remains unknown. Therefore, human tracheal epithelial cells were exposed to the clinically applied 20:1 mixture of cafedrine/theodrenaline and the individual substances separately. [Ca²⁺]_i wa

SUBMITTER: Schmidt G 

PROVIDER: S-EPMC10533847 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature