Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records.

ABSTRACT:

Background

Vasomotor symptoms (VMS) can often significantly impact women's quality of life at menopause. In vivo studies have shown that increased neurokinin B (NKB) / neurokinin 3 receptor (NK3R) signalling contributes to VMS, with previous genetic studies implicating the TACR3 gene locus that encodes NK3R. Large-scale genomic analyses offer the possibility of biological insights but few such studies have collected data on VMS, while proxy phenotypes such as hormone replacement therapy (HRT) use are likely to be affected by changes in clinical practice. We investigated the genetic basis of VMS by analysing routinely-collected health records.

Methods

We performed a GWAS of VMS derived from linked primary-care records and cross-sectional self-reported HRT use in up to 153,152

SUBMITTER: Ruth KS 

PROVIDER: S-EPMC10546673 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature