CD24⁺LCN2⁺ liver progenitor cells in ductular reaction contributed to macrophage inflammatory responses in chronic liver injury.

ABSTRACT:

Background

CD24⁺CK19⁺/CD24⁺SOX9⁺ resident liver cells are activated and expanded after chronic liver injury in a ductular reaction. However, the sources and functions of these cells in liver damage remain disputed.

Results

The current study combined genetic lineage tracing with in vitro small-molecule-based reprogramming to define liver progenitor cells (LPCs) derived from hepatic parenchymal and non-parenchymal tissues. tdTom⁺ hepatocytes were isolated from ROSA26^tdTomato mice following AAV8-Tbg-Cre-mediated recombination, EpCAM⁺ biliary epithelial cells (BECs) from wild-type intrahepatic bile ducts and ALB/GFP^-EpCAM^- cells were isolated from Alb^CreERT/R26^GFP</

SUBMITTER: Huang WJ 

PROVIDER: S-EPMC10546777 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature