Quantitative assessment of angioplasty-induced vascular inflammation with ¹⁹F cardiovascular magnetic resonance imaging.

ABSTRACT:

Background

Macrophages play a pivotal role in vascular inflammation and predict cardiovascular complications. Fluorine-19 magnetic resonance imaging (¹⁹F MRI) with intravenously applied perfluorocarbon allows a background-free direct quantification of macrophage abundance in experimental vascular disease models in mice. Recently, perfluorooctyl bromide-nanoemulsion (PFOB-NE) was applied to effectively image macrophage infiltration in a pig model of myocardial infarction using clinical MRI scanners. In the present proof-of-concept approach, we aimed to non-invasively image monocyte/macrophage infiltration in response to carotid artery angioplasty in pigs using ¹⁹F MRI to assess early inflammatory response to mechanical injury.

Methods

In eight minipigs,

SUBMITTER: Nienhaus F 

PROVIDER: S-EPMC10546783 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature