Urinary nicotine metabolites are associated with cognitive impairment among the elderly in southern China.

ABSTRACT:

Introduction

This study comprehensively assessed the association between eight metabolites of urinary nicotine and cognitive impairment.

Methods

This cross-sectional study was based on the data of Shenzhen Aging Related Disorder Cohort (SADC), including 51 elderly community data variables such as demographic characteristics, neuropsychological assessment and environmental factors, from July 2017 to November 2018. Participant's cognitive function was assessed by Mini-Mental State Examination (MMSE) scale and urinary nicotine metabolite [including cotinine N-β-D-glucuronide (CotGluc), rac 4-hydroxy-4-(3-pyridyl) butanoic acid dicyclohexylamine salt (HyPyBut), trans-3'-hydroxy cotinine O-β-D-glucuronide (OHCotGluc), and cotinine (Cot), etc.] concentrations were measured by high

SUBMITTER: Huang C 

PROVIDER: S-EPMC10548790 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature