Determination of genetic correlation between tobacco smoking and coronary artery disease.

ABSTRACT:

Backgrounds

Tobacco smoking is an important risk factor for coronary artery disease (CAD), but the genetic mechanisms linking smoking to CAD remain largely unknown.

Methods

We analyzed summary data from the genome-wide association study (GWAS) of the UK Biobank for CAD, plasma lipid concentrations (n = 184,305), and smoking (n = 337,030) using different biostatistical methods, which included LD score regression and Mendelian randomization (MR).

Results

We identified SNPs shared by CAD and at least one smoking behavior, the genes where these SNPs are located were found to be significantly enriched in the processes related to lipoprotein metabolic, chylomicron-mediated lipid transport, lipid digestion, mobilization, and transport. The MR analysis revealed

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC10562694 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature