A DEAD-box helicase drives the partitioning of a pro-differentiation NAB protein into nuclear foci.

ABSTRACT: How cells regulate gene expression in a precise spatiotemporal manner during organismal development is a fundamental question in biology. Although the role of transcriptional condensates in gene regulation has been established, little is known about the function and regulation of these molecular assemblies in the context of animal development and physiology. Here we show that the evolutionarily conserved DEAD-box helicase DDX-23 controls cell fate in Caenorhabditis elegans by binding to and facilitating the condensation of MAB-10, the C. elegans homolog of mammalian NGFI-A-binding (NAB) protein. MAB-10 is a transcriptional cofactor that functions with the early growth response (EGR) protein LIN-29 to regulate the transcription of genes required for exiting the cell cycle, terminal differen

SUBMITTER: Doi A 

PROVIDER: S-EPMC10584935 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature