Derivation and Validation of a New Equation for Estimating Free Valproate Concentration in Critically Ill Adult Patients.

ABSTRACT:

Importance

Protein binding of valproate varies among ICU patients, altering the biologically active free valproate concentration (VPAC). Free VPAC is measured at few laboratories and is often discordant with total VPAC. Existing equations to predict free VPAC are either not validated or are inaccurate in ICU patients.

Objectives

We designed this study to derive and validate a novel equation to predict free VPAC using data from ICU patients and to compare its performance to published equations.

Design

Retrospective cohort study.

Setting

Two academic medical centers.

Participants

Patients older than 18 years old with concomitant free and total VPACs measured in the ICU were included in the derivation cohort if admitted from 2014 to 2018, and the validation

SUBMITTER: Liu JT 

PROVIDER: S-EPMC10586844 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature