Constructing a prognostic model for head and neck squamous cell carcinoma based on glucose metabolism related genes.

ABSTRACT:

Background

Glucose metabolism (GM) plays a crucial role in cancer cell proliferation, tumor growth, and survival. However, the identification of glucose metabolism-related genes (GMRGs) for effective prediction of prognosis in head and neck squamous cell carcinoma (HNSC) is still lacking.

Methods

We conducted differential analysis between HNSC and Normal groups to identify differentially expressed genes (DEGs). Key module genes were obtained using weighted gene co-expression network analysis (WGCNA). Intersection analysis of DEGs, GMRGs, and key module genes identified GMRG-DEGs. Univariate and multivariate Cox regression analyses were performed to screen prognostic-associated genes. Independent prognostic analysis of clinical traits and risk scores was implemented using Cox

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10591078 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature