Non-canonical activation of IRE1α during Candida albicans infection enhances macrophage fungicidal activity.

ABSTRACT: While the canonical function of IRE1α is to detect misfolded proteins and activate the unfolded protein response (UPR) to maintain cellular homeostasis, microbial pathogens can also activate IRE1α, which modulates innate immunity and infection outcomes. However, how infection activates IRE1α and its associated inflammatory functions have not been fully elucidated. Recognition of microbe-associated molecular patterns can activate IRE1α, but it is unclear whether this depends on protein misfolding. Here, we report that a common and deadly fungal pathogen, Candida albicans, activates macrophage IRE1α through C-type lectin receptor signaling, reinforcing a role for IRE1α as a central regulator of host responses to infection by a broad range of pathogens. This activation did not depend o

SUBMITTER: McFadden MJ 

PROVIDER: S-EPMC10592910 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature