Viral activation and ecological restructuring characterize a microbiome axis of spaceflight-associated immune activation.

ABSTRACT: Maintenance of astronaut health during spaceflight will require monitoring and potentially modulating their microbiomes, which play a role in some space-derived health disorders. However, documenting the response of microbiota to spaceflight has been difficult thus far due to mission constraints that lead to limited sampling. Here, we executed a six-month longitudinal study centered on a three-day flight to quantify the high-resolution microbiome response to spaceflight. Via paired metagenomics and metatranscriptomics alongside single immune profiling, we resolved a microbiome "architecture" of spaceflight characterized by time-dependent and taxonomically divergent microbiome alterations across 750 samples and ten body sites. We observed pan-phyletic viral activation and signs of persisten

SUBMITTER: Tierney BT 

PROVIDER: S-EPMC10602132 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature