Identification of key genes and validation of key gene aquaporin 1 on Wilms' tumor metastasis.

ABSTRACT:

Background

Wilms' tumor (WT) is one of the most common solid tumors in children with unsatisfactory prognosis, but few molecular prognostic markers have been discovered for it. Many genes are associated with the occurrence and prognosis of WT. This study aimed to explore the key genes and potential molecular mechanisms through bioinformatics and to verify the effects of aquaporin 1 (AQP1) on WT metastasis.

Methods

Differentially expressed genes (DEGs) were generated from WT gene expression data sets from the Gene Expression Omnibus (GEO) database. Gene functional enrichment analysis was carried out with the Database for Annotation, Visualization and Integrated Discovery (DAVID). A protein-protein interaction network (PPI) was constructed and visualized by the Search Tool for

SUBMITTER: Liu H 

PROVIDER: S-EPMC10613441 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature